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Blood coagulation or blood clotting, is an important process to stop the bleeding at a wound site.
10 Arbeidsdager
Spesifikasjoner
| Breeds | Amerikansk korthår, Balineser, Highlander, Himalayan, Manx, Napoleon, Siameser, Tennessee Rex, Bengal, Maine Coon, Munchkin, Ragdoll, Savannah |
|---|---|
| Gene | |
| Organ | |
| specimen | Svaber, EDTA blod, heparinblod, sæd, vev |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
Generell informasjon
Blood coagulation or blood clotting, is an important process to stop the bleeding at a wound site. This process is mediated by multiple factors contributing to the coagulation cascade. One of these factors is plasma coagulation factor XII (factor 12, FXII or F12).
This test detects a DNA variant that is associated with a severe decrease in FXII activity causing difficulties in blood coagulation. It is found in several breeds, thoug is less widespread as the other variant offered.
Kliniske egenskaper
This variant leads to FXII deficiency, resulting in the absence of detactable factor XII in the cat's blood plasma. Cats homozygous for this mutation have a severe deficiency and will likely have an increased tendency to bleeding after surgery or (minor) trauma. Cats that are heterozygous have a moderate reduction in FXII activity.
Tilleggsinformasjon
In literature an autosomal recessive inheritance pattern is suggested, but also describes mild clinical features in cats heterozygous for this variant.
Referanser
Pubmed ID: 24793828
Omia ID: 364